A pancreaticoduodenectomy, pancreatoduodenectomy, Whipple procedure, or Kausch-Whipple procedure, is a major surgical operation most often performed to remove cancerous tumours of the head of the pancreas. It is also used for the treatment of pancreatic or duodenal trauma, or chronic pancreatitis. Due to the shared blood supply of organs in the proximal gastrointestinal system, surgical removal of the head of the pancreas, also necessitates removal of the duodenum, proximal jejunum, gallbladder, and, occasionally, part of the stomach.

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